Your health risks - discuss results from yourDNAportal

Discuss yourDNAportal genetic health risks results
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Sulis Great Britain
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Re: Your health risks - discuss results from yourDNAportal

Post by Sulis » Sun Feb 03, 2019 11:36 am

Incidence of Celiac/Coeliac disease are high in northern Europe, particularly in Ireland and Scandinavia (Sweden having the highest rate). The diet in Ireland before the potato famine was virtually gluten free. Before the potato, oats were the staple not wheat. After the famine when wheat became more common, celiac disease became a problem.

Ironically, Italy the country where pasta, pizza and bread are dietary staples also has a very high incidence of celiac disease.

https://www.ncbi.nlm.nih.gov/pubmed/11478502

https://www.lunduniversity.lu.se/articl ... ac-disease

"Ireland was first settled 9,000 years ago and the first farmers arrived 6,000 years ago. Irish agriculture became dominated by pasture. Milk products were central to the Irish diet. Although cereal was eaten, it was largely in the form of oats. Ireland's basic human genetic stock was established 5,000 years ago and has remained relatively homogenous and distinct ever since.

The diet of the planters of the 16th and 17th century was cereal-based. The planter farmers displaced the native Irish to poor land where tillage was difficult. Commercialisation also made dairy products and oats more expensive and these items were progressively lost from the diet of the poor. The potato became important. Oats were the only cereal and source of gluten consumed before the Famine. Wheaten bread became a staple of the Irish diet only with the dietary changes that followed the Famine and the Irish diet now differs little from elsewhere in the western world.

From prehistory until relatively recently, the Irish diet has been very low in gluten. This allowed gluten-intolerant genetic traits to persist. Our relatively high incidence of coeliac disease is explained by our dietary past.

William Reville is associate professor in biochemistry and director of Microscopy at UC"

"https://www.irishtimes.com/news/how-iri ... -1.1054583

Celiac disease rates in India-
"Importantly, celiac disease was significantly more common among patients from the Punjab region of India (3.1%) than among other North Indians (1.5%; P
= .02)."
https://www.mdedge.com/gihepnews/articl ... njab-study
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OttrChris United States of America
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Re: Your health risks - discuss results from yourDNAportal

Post by OttrChris » Mon Feb 04, 2019 1:21 am

Thank y’all again ! (I’m from the South in the US)
I’ve been very mindful in upping my intake of cruciferous vegetables and am eating a good bit of organic broccoli, Brussels sprouts and kale. Being part Italian-American, I grew up eating lots of broccoli with olive oil and fresh pressed garlic. I found a few interesting articles on the effectiveness of broccoli with oncogene can suppression in both bladder and prostate cancers. It’s quite amazing. Especially in comparison to existing chemotherapies which are quite barbaric and some with only a 3% efficacy rate. That is pretty poor. Here are the article. Hope you enjoy.

1. Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate:

https://www.ncbi.nlm.nih.gov/pubmed/18596959/

2. Sulforaphane and prostate cancer interception.

https://www.ncbi.nlm.nih.gov/pubmed/25051139/

3. Broccoli Fights Cancer by Clearing Bad Tumor Suppressors

https://www.scientificamerican.com/podc ... -11-01-27/

In closing I have a question, of course! My analysis showed that i carry alleles which indicate various increases in risk for prostate cancer. I would like to understand what the risk variables indicate. One is 1.6x and another 1.3x increased risk. Could you quantify this in terms relative to potentiality of PC creeping up on me. I’m concerned with this and bladder cancer. I know we can try to limit exposure to chemicals, eat the right foods and whatnot to help influence the genes from expressing themselves, but at 1.6x and 1.3x, what is the probability that cancer will eventually manifest itself. Is there a point where the gene are expressing themselves so vividly that any intervention is futile? Is it always possible to influence gene expression to a small degree? (I’m hoping with a good diet, to a large degree!)

Right, thanks again and I look forward to anyone’s response.

The last link I’m posting is from our NIH (Nat’l Inst of Health)
It’s a clear and concise summary of genetics in relation to prostate cancer.

Genetics of Prostate Cancer (PDQ®)–Health Professional Version


https://www.cancer.gov/types/prostate/h ... netics-pdq

My best,

Christopher
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BrGilbert Australia
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Re: Your health risks - discuss results from yourDNAportal

Post by BrGilbert » Sat Feb 23, 2019 2:42 am

Fragile X is in my family. I wish I could tell if I have it as a carrier by looking at my dna results.

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Re: Your health risks - discuss results from yourDNAportal

Post by royalfortune » Fri Jun 14, 2019 12:11 pm

Hi

My Health results are in and Im very concerned about the below. Has anyone else had this?

Prion Disease

People with your genotype have an increased chance of Prion Disease (CJD)
Increased chance of Prion Disease (CJD) (PrP 129 Met homozygote). This SNP has been linked with a higher risk for sporadic Creutzfeldt-Jakob disease, with homozygotes of both types seemingly at increased risk compared to heterozygotes.
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Re: Your health risks - discuss results from yourDNAportal

Post by Sulis » Fri Jun 14, 2019 6:21 pm

royalfortune wrote:
Fri Jun 14, 2019 12:11 pm
Hi

My Health results are in and Im very concerned about the below. Has anyone else had this?

Prion Disease

People with your genotype have an increased chance of Prion Disease (CJD)
Increased chance of Prion Disease (CJD) (PrP 129 Met homozygote). This SNP has been linked with a higher risk for sporadic Creutzfeldt-Jakob disease, with homozygotes of both types seemingly at increased risk compared to heterozygotes.
You only develop Prion disease if you have eaten contaminated meat. The normal result that most people get is a higher chance of developing it, only heterozygotes are protected from developing it. So do not worry! We had the “Mad cow disease” scandal in the U.K. where we had to destroy many of our cows because they’d been eating infected cow feed made with animal derived protein (not a good idea to feed herbivorous animals, animal protein derived food) from the U.S. The chances of developing it are low and not something to be unduly concerned by.

https://www.urmc.rochester.edu/encyclop ... tID=P01444
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tdd85 United States of America
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Re: Your health risks - discuss results from yourDNAportal

Post by tdd85 » Fri Jun 14, 2019 7:07 pm

MTHFR, Folate Metabolism

People with your genotype have 2 variants associated with Folate Metabolism (MTHFR): homozygous (2 copies) for C677T of MTHFR


Vitamin B6

People with your genotype have lower vitamin B6 blood concentration
Lower vitamin B6 blood concentration: 1.45 ng/mL


Heart Disease and Stroke

People with your genotype have an average risk of heart disease and stroke
Normal


Type 2 Diabetes

People with your genotype are at increased risk for type-2 diabetes
Maintaining a healthy weight and exercising may improve outlook. (CC) 3 increased risk for type-2 diabetes.


Prostate Cancer

People with your genotype have a normal risk for prostate cancer
Good. Normal risk.


Breast Cancer

People with your genotype have a normal risk for this variant
Good. Normal. One of many variants associated with breast cancer risk. (CC) normal.


Vitamin D

People with your genotype have average serum levels of vitamin D
Average serum levels of vitamin D


Celiac Disease

People with your genotype have an increased risk for celiac disease
Increased risk for celiac disease. If diagnosed with celiac disease, avoidance of gluten (from grains) improves health


Vitamin B12

People with your genotype have normal serum levels of vitamin B12
Normal serum levels of vitamin B12
(I went to the doctor a couple days ago and had my blood drawn, my b12 levels were pretty low)



Prion Disease

People with your genotype have resistance to Prion Disease (CJD)
Very Good. Resistance to Prion Disease (CJD) (PrP 129 Met/Val heterozygote)


Skin Cancer

People with your genotype do not have an increased risk, but may carry other variants.
No increased risk for this genotype but may have other variants.

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Re: Your health risks - discuss results from yourDNAportal

Post by calpal » Fri Nov 20, 2020 2:14 am

Vitamin B6
rs4654748CT
Gene: NBPF
People with your genotype have lower vitamin B6 blood concentration

Lower vitamin B6 blood concentration: 1.45 ng/mL

Vitamin D
rs2060793GG
Gene: CYP2R1
People with your genotype have higher serum levels of vitamin D

Higher serum of levels of vitamin D

Vitamin B12
rs492602AG
Gene: FUT2
People with your genotype have normal serum levels of vitamin B12

Normal serum levels of vitamin B12

Prion Disease
rs1799990AG
Gene: PRNP
People with your genotype have resistance to Prion Disease (CJD)

Very Good. Resistance to Prion Disease (CJD) (PrP 129 Met/Val heterozygote)

MTHFR, Folate Metabolism
rs1801133AG
Gene: MTHFR
People with your genotype have one variant associated with Folate Metabolism (MTHFR): 1 copy of C677T allele of MTHFR

1 variant partially applicable. AG 1 copy of C677T allele of MTHFR 60% efficiency in processing folic acid could have somewhat elevated homocysteine and low B12 and folate levels. Also known as C677T, Ala222Val, and A222V, it one of the variants in the MTHFR gene, which encodes an enzyme involved in folate metabolism. Homozygous rs1801133AA have 30% of the expected MTHFR enzyme activity, and rs1801133(CT) heterozygotes have 65% activity, compared to the most common genotype, rs1801133GG. Folic Acid (the synthetic form of folate found in many vitamin Supplements) should be avoided. The natural forms of folate from food, or supplementation with L-methyltetrahydrofolate should be increased.

Type 2 Diabetes
rs13266634CC
Gene: SLC30A8
People with your genotype are at increased risk for type-2 diabetes

Maintaining a healthy weight and exercising may improve outlook. (CC) 3 increased risk for type-2 diabetes.

Celiac Disease
rs3184504CC
Gene: SH2B3
People with your genotype have a normal risk for celiac disease

Good. Normal.

Prostate Cancer
rs6983267GT
Gene: CASC8
People with your genotype are at a 1.3x risk of prostate cancer

Aspirin may reduce the risk of colorectal cancer. If taking, always take a coated aspirin to protect from stomach bleeds. (GT) 1.3x risk of prostate cancer.

Heart Disease and Stroke
rs2943634CC
People with your genotype have a higher risk of ischemic stroke

Higher risk of ischemic stroke. Associated with heart disease and stroke. (CC) 2.5 higher risk of ischemic stroke.

Breast Cancer
rs2981582AG
Gene: FGFR2
People with your genotype have a 1.3x higher risk of ER+ breast cancer

One of many variants associated with breast cancer risk. (CT) 1.3x higher risk of ER+ breast cancer.

Skin Cancer
rs910873GG
Gene: PIGU
People with your genotype do not have an increased risk, but may carry other variants.

No increased risk for this genotype but may have other variants.
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